Abstract—The spread of continuous indwelling sensors in the subcutaneous tissue has enabled continuous monitoring of interstitial fluid glucose concentration (ISFG) under daily activities. This technology is considered to enable the development of a method for evaluating glycemic control function by analyzing not only the detailed state of diabetes and other pathological conditions but also the characteristics of glycemic dynamics. To clarify the basic fluctuation characteristics of long-term ISFG, the spectral structure and nonlinear dynamics properties of ISFG obtained by continuous monitoring for 11 days were analyzed in healthy and diabetic subjects.

Index Terms—Blood glucose, diabetes, heart rate variability, interstitial fluid glucose, spectral analysis.

Junichiro Hayano is with Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan. Atsushi Yamada is with Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan; Oriental Medical Center Group Futaba Acupuncture and Moxibustion Clinic, Anjo, Aichi, Japan. Yutaka Yoshida is with Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan; Nagoya City University Graduate School of Design and Architecture, Nagoya, Japan. Norihiro Ueda is with Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan. Emi Yuda is with Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan; Tohoku University Graduate School of Engineering, Sendai, Japan.

Cite: Junichiro Hayano, Atsushi Yamada, Yutaka Yoshida, Norihiro Ueda, Emi Yuda, "Spectral Structure and Nonlinear Dynamics Properties of Long-Term Interstitial Fluid Glucose," International Journal of Bioscience, Biochemistry and Bioinformatics vol. 10, no. 3, pp. 137-143, 2020.

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