Abstract—Parkinson’s Disease(PD) is a common progressive neurodegenerative disorder caused by both genetic and environmental risk factors, at least 25 genetic loci and 20 genes have been identified in monogenic PD. In 1998, Thomas Gasser described a genetic locus on chromosomal location 2p13, called PARK3. The monogenic gene of PARK3 is still unknown. To explore the genetic cause of PD and potential candidates for the PARK3 locus, gene expressions and biological pathways were closely analyzed between 6 known PD-associated genes and the genes on 2p13. By excluding non-pathogenic variants from the current research, this study proposes 3 genes - AAK1, EXOC6B, and SEMA4F - should be extensively researched as potential genetic factors of PD and probable PARK3 locus, and more clinical data are necessary for predicting new genetic variants.

Index Terms—Biologica l pathway, PARK3, parkinson’s disease , RPKM.

The author is with the Hill School, 301 W 53rd St., New York, NY, 10019, USA (email: caijingyududu@gmail.com).

Cite: Jingyu Cai, "Identifying Genes on 2p13 as Potential Genetic Factors of Parkinson’s Disease and PARK3 Locus Candidate," International Journal of Bioscience, Biochemistry and Bioinformatics vol. 8, no. 4, pp. 245-251, 2018.