DOI: 10.7763/IJBBB.2011.V1.4
Quercetin Delivery into Cancer Cells with Single Walled Carbon Nanotubes
Abstract—Carbon nanotubes are made up of carbon atoms arranged in a series of condensed benzene rings and wrapped into a tubular form. They represent a new allotrope of carbon invented from fullerene family, which can be described as rolled up graphite sheets held together by van der Waals bonds. These materials due to some qualities such as high specific surface area, unique electrical and electronical properties are used in many applications as catalyst base, polymers mechanical strengthening, composites, electronical devices production and drug delivery. Especially, they are able to cross through cell wall and inter to cell nucleus. This work speculates on methods of design, synthesis, and quercetin delivery as an antioxidant agent that its anticancer function has been reported, by single-walled carbon nanotubes (SWCNTs) into cancer cells and their detection method. In fact, we introduce the concept of “functionalization partitioning” of SWCNTs, i.e., imparting various chemical species, such as poly (ethylene glycol) (PEG), quercetin with different functionalities into the surface of the SWCNTs. And we will discuss how binding of molecules to SWCNTs and their release can be controlled by varying the pH.
Index Terms—Component; Carbon nanotubes; Quercetin, Drug delivery.
Jafar Ezzati Nazhad Dolatabadi is with Research Center for Pharmaceutical Nanotechnology, Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran (corresponding author phone: +98 411 3367914, fax: +98 411 3367929; e-mail: ezzati_j@yahoo.com).
Ali Akbar Jamali is with Member of Young Researchers Club, Islamic Azad University, Tabriz branch, Tabriz, Iran.
Mohammad Hasanzadeh is with Drug Applied Research Center, Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Yadollah Omidi is with Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran.
Cite: Jafar Ezzati Nazhad Dolatabadi, Ali Akbar Jamali, Mohammad Hasanzadeh, Yadollah Omidi, "Quercetin Delivery into Cancer Cells with Single Walled Carbon Nanotubes," International Journal of Bioscience, Biochemistry and Bioinformatics vol. 1, no. 1, pp. 21-25, 2011.
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