Abstract—Cadmium (Cd) are heavy metals which used in many industry and were confirmed as an environmental toxin and mainly effects haematological system and liver. Previous studies showed that Cd induced damage of the liver and influence erythrocytes. The effect of Cd in haematological system and liver function especially in pregant women has not been much studied. Thus our study aimed to evaluate the potential effect of cadmium exposure on erythrocytes and liver function in pregnant women by measuring their correlation on the number of erythrocytes and the levels of Aspartate Transaminase (AST) and Alanine Transmainase (ALT). This study was performed between July to December 2013 and targeted 58 pregnant women who were admitted for treatment and termination of pregnancy due to medical or obstetrical indications in Mutiara Bunda Mother and Child Hospital, Martapura, South Kalimantan, Indoneseia. For analyzing of the data, SPSS software version 17 was used and was examined by Pearson correlation test. We found that Cd has a negative correlation with erythroctes cell count and ALT levels and positive correlation with AST levels, but the three correlation are not significanct on statistical analysis. It can be concluded form our results Cd caused erythrocytes cells and tissue damage but does not caused liver damage.

Index Terms—Alanine transaminase, aspartate transmainase, cadmium, erythrocytes, pregnant women.

Adjar Wibowo is with the Obstetry and Gynecology Department Ulin General Hospital/Faculty of Medicine Lambung Mangkurat University, Indonesia (e-mail: Adjarwibowo@yahoo.com).
Firrar Artmi Rahaju is with the Mutiara Bunda Mother and Child Hospital, Martapura, South Kalimantan, Indonesia (e-mail: fir_art@yahoo.com).
Iskandar is with Research Unit Mutiara Bunda Mother and Child Hospital, Martapura of South Kalimantan, Indonesian (e-mail: Iskandarthalib@gmail.com).
Eko Suhartono is with Environmental Science and Technology Graduate Program, University of Brawijaya, Malang, Indonesia and Medical Chemistry/Biochemistry Department Faculty of Medicine University of Lambung Mangkurat, Banjarmasin, Indonesia (e-mail: ekoantioxidant@gmail.com).

Cite: Adjar Wibowo, Firrar Artmi Rahaju, Iskandar, and Eko Suhartono, "The Role of Urinary Cadmium on Liver Function and Erythrocytes Cell Count in Pregnancy," International Journal of Bioscience, Biochemistry and Bioinformatics vol. 4, no. 4, pp. 224-228, 2014.