Abstract—Neonatal sepsis is a clinical syndrome of bacteremia and divided into two different types, early-onset neonatal sepsis and late-onset neonatal sepsis. Sepsis promotes the unbalanced production of oxidant and anti-oxidant substances, causing an excess of free oxygen compounds. Early markers of neonatal sepsis have been studied in recent years, and this study proposed another parameter to detect early-onset neonatal sepsis with the use of advance oxidation protein products (AOPPs). This study was conducted in April - June 2012, saliva and serum specimens were taken from 81 newborns, in which 39 infants were at risk of sepsis and 42 infants were healthy and served as a control group. Data was analyzed by using Mann-Whitney test and Spearman correlation test. This study suggested that there is significant difference between AOPPs level on the case group compare to the control group. This study also found that there is significant difference between salivary AOPPs level compare to serum AOPPs level. As the conclusion, this study proposed that the AOPPs parameter may be used as another marker to detect early-onset neonatal sepsis.

Index Terms—Early-onset neonatal sepsis, free oxygen compounds, AOPPs.

Ari Yunanto is with the Pediatric Department Ulin General Hospital/ Faculty of Medicine Lambung Mangkurat University, Banjarmasin, Indonesia (e-mail: ariefkaunlam@gmail.com).
Rizky Taufan Firdaus is with the Reserch Unit on Maternal and Perinatal Mutiara Bunda Mother and Child Hospital, Martapura, Indonesia (e-mail: weiki_5150@yahoo.com).
Triawanti and Eko Suhartono are with the Medical Chemistry, Biochemistry Department Faculty of Medicine Lambung Mangkurat University, Banjarmasin, Indonesia (e-mail: tria_fkunlam@yahoo.co.id; ekoantioksidan@yahoo.com).

 

Cite: Ari Yunanto, Rizky Taufan Firdaus, Triawanti, and Eko Suhartono, "Advance Oxidation Protein Products (AOPPs) of Newborn at Risk of Sepsis as Novel Parameter for Early-Onset Neonatal Sepsis," International Journal of Bioscience, Biochemistry and Bioinformatics vol. 4, no. 2, pp. 90-93, 2014.