Abstract—The study is investigating prospectively the potentials of applying liposome as computed tomography (CT) contrast agent delivery vesicle for prevention of contrast medium induced nephropathy (CIN) incidence both in vitro and in vivo. From dynamic CT of nude mice, we found that partial encapsulation of CM in liposome increased the indication of biliary excretion up to 12 folds post CM administration, and reduced the concentration and duration of CM accumulation in kidney. From Madin–Darby canine kidney epithelial cell line (MDCK) viability studies, it showed that fully encapsulation of CM in liposome significantly improved the cell viability when exposed to clinical concentration of CM for 24 hours.

Index Terms—Liposome, contrast medium, contrast medium induced nephropathy.

Gi-Da Lee and Jyn-Wen Chai are with the Department of Radiology, Taichung Veterans General Hospital, Taichung City, 40705, Taiwan, Republic of China (e-mail: lee.gida@msa.hinet.net, hubt@mail.vghtc.gov.tw).
Li-Che Hu, Pei-Hsuan Lu, and Kuo-Chih Liao are with the Graduate Institute of Biomedical Engineering, National Chung-Hsing University, 250 Kuo-Kuang Rd., Taichung City, Taiwan, 40227, Republic of China. (e-mail: jackjackjack46@yahoo.com.tw, starwithshadow@hotmail.com, kcliao@dragon.nchu.edu.tw).

 

Cite:Gi-Da Lee, Jyn-Wen Chai, Li-Che Hu, Pei-Hsuan Lu, and Kuo-Chih Liao, "Prevention of Contrast Medium Induced Nephropathy by Liposome Encapsulation," International Journal of Bioscience, Biochemistry and Bioinformatics vol. 3, no. 6, pp. 562-565, 2013.