Abstract—Analyzing the differential genetic traits related to senescence of the long-lived naked mole-rat and various species that are convergent phylogenetically, by a combination of bioinformatic algorithms with nucleotide genomic signal processing, and hierarchical cluster methods. Since the naked mole-rat has distinctive aging resistance, comparing the aging-related genes may guide to essential differences in pathological incidences of aging diseases among the species concerned.

Index Terms—Aging-related genes, DNA damage, neurodegenerative diseases, naked mole-rat (Heterocephalus glaber).

Layal Abo Khayal is with the Brno University of Technology, Faculty of Electrical Engineering and Communication, Department of Biomedical Engineering, Czech Republic (e-mail: khayal@phd.feec.vutbr.cz).
Ivo Provaznik is with the International Clinical Research Center - Center of Biomedical Engineering, St. Anne's University Hospital Brno, Brno, Czech Republic, and with Brno University of Technology, Faculty of Electrical Engineering and Communication, Department of Biomedical Engineering, Czech Republic (e-mail: provaznik@feec.vutbr.cz).
Ewaryst Tkacz is with the Silesian University of Technology, Faculty of Biomedical Engineering and with Brno University of Technology, Faculty of Electrical Engineering and Communication, Department of Biomedical Engineering, Czech Republic (e-mail: tkacz@feec.vutbr.cz).

 

Cite:Layal Abo Khayal, Ivo Provaznik, and Ewryst Tkacz, "Differential Analysis of Neurodegenerative Aging-Related Mitochondrial Genes of Long-Lived Naked Mole-Rat," International Journal of Bioscience, Biochemistry and Bioinformatics vol. 3, no. 2, pp. 75-79, 2013.