Abstract—The aim of this work is to evaluate the hepatoprotective effect of garlic homogenate co-administered with anti-tuberculosis drugs on the liver. Twenty rats were divided into five groups (each of four rats) designated A, B, C, D and E (control). 51.4mg/kg body weight of first line tuberculosis drugs (Isoniazid, Rifampicin, Pyrazinamide and ethambutol) was administered orally to two (2) rats in group A, B, C, and D for seven (7) days and the remaining two rats in each group for twenty-eight (28) days. 28.5 mg/kg, 42.8 mg/kg and 57.1 mg/kg body weight of the garlic were co-administered with the anti-tuberculosis drugs to group (B), (C) and (D) respectively. Group (A) serve as negative control. From the results obtained, it was observed that the values of AST, ALT and ALP were significantly higher in rats administered with 51.4 mg/kg of first line anti -TB drugs (negative control) when compared with rats co-administered with same anti-TB drugs and 57.1 mg/kg of garlic homogenate. (P<0.05).The AST and ALT levels were found to increase progressively as garlic concentration decreases. This result has also showed that anti-tuberculosis drugs are hepatotoxic from the values (AST: 47.5 ± 3.53, ALP: 87.0 ± 4.24 and ALT: 52.0± 4.24) obtained in group A (negative control) when compared to group E (positive control) values (AST: 10 ± 1.41, ALP: 33 ± 4.24 and ALT: 10 ± 4.24). There were no significance differences obtained in the level of AST and ALT when compared with seven (7) days treatment. Histological test was done to confirm the results obtained. From this work it can be suggested that supplementation of garlic in individuals on first line anti-TB drugs may be beneficial as garlic proves to be hepatoprotective. The hepatoprotective effect of garlic is dose dependent.

Index Terms—Alanine transaminase (ALT), alkaline phosphatase (ALP), aspartate transaminase (AST), tuberculosis (TB).

The authors are with the Department of Biochemistry, Faculty of Science, Bayero University Kano, Nigeria (e-mail: nasiruabdullahi@yahoo.com).

Cite: Nasiru A., Hafsat. I. G., Mohammad M. M., and Sabo A. A., "Hepatoprotective Effect of Garlic Homogenate Co-Administered with Anti-Tuberculosis Drugs in Rat Liver Enzymes," International Journal of Bioscience, Biochemistry and Bioinformatics vol. 2, no. 5, pp. 354-357, 2012.