Abstract—Kinetic Modeling of a process in biochemical system has long been pursued with the aim of understanding the metabolic processes for the human system. Kinetic models that are based on elementary reactions give the best accuracy and reliability. Platelets, an important component of blood, play a major role in hemostasis, which aids in the formation of blood clots. Platelet aggregation is the clumping together of platelets in the blood. The process of converting the blood from a liquid to a solid state is called Thrombus. Platelet Aggregation is a part of the sequence of reactions leading to the formation of a Thrombus. The objective of this paper is to use kinetic modeling to study the processes of Thrombin Induced Platelet Aggregation (TIPA) and Collagen Induced Platelet Aggregation (CIPA) pathways in human system, simulate these pathways using CellDesigner and find the target drugs having antiplatelet potency.

Index Terms—Platelet aggregation, receptors, biopathways, thrombin, collagen.

K M Prakash Lingam and Venugopal K R are from University Visvesvaraya College Of Engineering Bangalore, India.
L M Patnaik is with Defence Institute of Advanced Technology, Pune, India (Tel: +91-9986629067, email: kmplingam@hotmail.com)

Cite: K. M. Prakash Lingam, Venugopal K. R., and L. M. Patnaik, "Kinetic Modeling of Thrombin Induced and Collagen Induced Platelet Aggregation Pathway–A System Biology Approach," International Journal of Bioscience, Biochemistry and Bioinformatics vol. 1, no. 3, pp. 184-191, 2011.